Ytrium 90 as a radionuclide for therapy
Main Article Content
Abstract
Is a pure beta emitter with a half-life of 64.1h and 2.28 MeV of energy, suitable properties for its use as a therapeutic radionuclide. Radiopharmaceuticals based on have been effectively used in the treatment of different diseases such as chronic synovitis, liver cancer, pain caused by bone metastases and neuroendocrine tumors. The results in the treatment of no-Hodgkin lymphoma, that combine the specificity of a monoclonal antibody for CD20 antigen and the pure beta energy of , deserve a particular distinction. Although the half-life of makes possible its transportation, it is sold at high prices for a systematic or large-scale use. The fact that can be produced through a radionuclide generator system, based on the secular equilibrium of decaying to , is very attractive for developing a local production because the cost could be significantly reduced and availability could be guaranteed. The present work shows the ways to obtain , the aspects related to the quality of final product, the main applications and the results achieved by the Isotope Centre in this area.
Article Details
How to Cite
Alberti Ramírez, A. (1). Ytrium 90 as a radionuclide for therapy. Nucleus, (52). Retrieved from http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/574
Section
Ciencias Nucleares
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2. GOING JE, ROBERTS CA, DANCEY JE, et. al. Treatment of unresectable metastatic coloretal carcinoma to the liver with intrahepatic microspheres: Dose-ranging study. World J Nucl. Med. 2003; 2(3): 216-225.
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4. KUTZNER J, DAHNERT W, SCHREYER T, et. al. Treatment of pains from bone metastases with 90Y. Nuklearmedizin. 1981; 20(5): 229-35.
5. MULTIBONE (EDTMP) (Y-IK-26) Summary of Product Characteristics. (Prospecto médico).
6. DAVIES AJ. Radioimmunotherapy for B-cell lymphoma: Y-90 ibritumomab
tiuxetan and I-131 tositumomab. Oncogene, 2007; 26(25): 3614-28.
7. CHAKRAVARTY R, PANDEY U, MANOLKAR RB, et. al. Development of an electrochemical 90Sr-90Y generator for separation of 90Y suitable for targeted therapy. Nucl. Med. Biol. 2008; 35(2): 245-253.
8. WESTER DW, STEELE RT, RINEHART DE, et. al. Large scale purification of 90Sr from nuclear waste materials for production of 90Y, a therapeutical medical radioisotope. Appl. Radiat. Isot.. 2003; 59(1): 35-41.
9. CHINOL M, HNATOWICH DJ. Generator produced yttrium-90 for radioimmunotherapy. J. Nucl. Med. 1987; 28(9): 1465-1470.
10. KODINA GE. Preparation of high-purity radionuclide 90Y in specially designed centrifugal semicounterflow extractors. Radiochemestry. 2002; 44(1): 62-66.
11. RAMANUJAM A, ACHUTHAN PV, DHAMI PS, et. al. Separation of carrier-free 90Y from high level waste by supported liquid membrane using KSM-17. J Radioanal Nucl Chem. 2001; 247(1): 185-191.
12. SYLVESTER P. Novel ion exchange materials for the separation of 90Y from 90Sr. Patent US 20030231994. 2003.
13. WIKE JS, GUYER CE, RAMEY DW, PHILLIPS BP. Chemistry for Commercial Scale Production of Yttrium-90 for Medical Research. Appl. Radiat. Isot. 1990; 41(9): 861-865.
14. XIQUES A, PÉREZ M, ISAAC K, et. al. Production of large quantities of 90Y by ion-exchange chromatography using an organic resin and a chelating agent. Nucl. Med. Biol. 2010; 37(8): 935-942.
15. XIQUES A, ISAAC K, CASANOVA E, et. al. An adapted purification procedure to improve the quality of 90Y for clinical use. Radiochim. Acta . 2009; 97(12): 739-746.
16. LIU S, EDWARDS DS. Bifunctional chelators for therapeutic lanthanide radiofarmaceuicals. Bioconjug Chem. 2001; 12(1): 7-34.
17. MALJA S, SCHOMACKER K, MALJA E. Preparation of 90Y by the 90Sr-90Y Generator for Medical Purpose. J Radioanal. Nucl. Chem. 2000; 245(2): 403-406.
18. United States National Bureau of Standards. Maximum permissible body burden and maximum permissible concentrations of radionuclides in air and water for occupational exposure: recommendations. Handbook. Volumen 69. 1959. p. 38.
19. PANDEY U, DHAMI PS, JAGESIA P, VENKATESH M, PILLAI MR. Extraction Paper Chromatography Technique for the Radionuclidic Purity Evaluation of 90Y for Clinical Use. Anal. Chem. 2008; 80(3): 801-807.
20. BREEMAN WA, KWEKKEBOOM DJ, DE BLOIS E, et. al. Radiolabelled regulatory peptides for imaging and therapy. Anticancer Agents. Med Chem 2007; 7(3): 345-7.
21. GULEC SA, MESOLORAS G, DEZARN WA, et. al. Safety and efficacy of Y-90 microsphere treatment in patients with primary and metastatic liver cancer: the tumor selectivity of the treatment as a function of tumor to liver flow ratio. J. Trans. l Med. 2007; 5: 15.
22. KWEKKEBOOM DJ, MUELLER-BRAND J, PAGANELLI G, et. al. Overview of results of peptide receptor radionuclide therapy with three radiolabelled somatostatin analogs. J Nucl Med. 2005; 46 (Suppl 1):62S-6S.