Phagocytosis in phosphate chromium (III) suspensions
Main Article Content
Abstract
Phagocytosis in vivo and in vitro of a suspension of chromic phosphate (III) labeled with and is studied. The radioactive particles dispersed in a media of 2 % gelatin in acetate buffer pH 4-4.5 have a predominant size of 0.8 ?m and 5 ?m. According with biodistribution experiments in rats after 30 minutes near the 80 % of radioactivity is registered in the liver, probably associated with phagocytosis of the particles by liver Kupffer cells. Is also showed that the suspension particles are phagocytized in vitro by mouse peritoneal macrophages. This facts indicate that the studied suspension have appropriate characteristics to be used in adiosynoviorthesis according to the principal action mechanism described for this procedure, particles phagocytosis by cells present in the inflamed synovium.
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How to Cite
Cruz Arencibia, J., Fano Machín, Y., Cruz Morales, A., Tamayo Fuente, R., & Morín Zorrilla, J. (1). Phagocytosis in phosphate chromium (III) suspensions. Nucleus, (57). Retrieved from http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/600
Section
Ciencias Nucleares
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References
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[2] SCHNEIDER P, FARAHATI J, REINERS C. Radiosynovectomy in rheumatology, orthopedics and hemophilia. J. Nucl. Med. 2005; 46 (suppl 1): 48S–54S.
[3] LLINÁS A. The role of synovectomy in the management of a target joint. Hemophilia World Congress. 2008. June 1-5. Istanbul, Turkey.
[4] KROPÁCEK M, MELICHAR F, SRANK J, et. al. Preparation and quality control of [166Ho]-macroaggregates for radiosynoviorthesis. Cancer Biother Radiopharm. 2007; 22(3): 450-452.
[5] PANDEY U, KETAKI B, GRACE S, et. al. Evaluation of 90Y phosphate particles as a possible radiation synoviorthesis agent. Nucl Med Commun. 2005; 26(5): 459-463.
[6] SRIVASTAVA SC. The role of electron-emitting radiopharmaceuticals in the palliative treatment of metastatic bone pain and for radiosynovectomy: applications of conversion electron emitter Tin-117m. Braz Arch Biol Technol. 2007; 50: 49-62.
[7] UNNI PR, VENKATESH CHM, RAMAMOORTHY N, PILLAI MRA. Preparation and bioevaluation of 166Ho labeled hydroxyapatite (HA) particles for radiosynovectomy. Nucl. Med. Biol. 2002; 29(2):199-209.
[8] NOBLE J, JONES AG, DAVIS MA et. al. Leakage of radioactive particle systems from a synovial joint studied with a gamma camera. Its application to radiation synovectomy. J. Bone Joint Surg. Am. 1983; 65(3): 381-389.
[9] BUTOESCU IN, JORDAN O, DOELKER E. Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance. Eur J Pharm Biopharm. 2009; 73(2): 205-218.
[10] GHADIALLY FN, Overview article: the articular reticuloendothelial system. Ultrastructural Pathology.1980; 1(2): 249-264.
[11] CRUZ ARENCIBIA J, MORÍN ZORRILLA J, CRUZ MORALES A, et. al. Fosfato de cromo (III) marcado con diferentes radionúclidos para uso en radiosinoviortesis. Rev Cub Farm. 2012; 46 (2): 162-172.
[12] BROWN RP, DELP MD, LINDSTEDT SL. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health. 1997; 13(4): 407-484.
[13] CARDOSO M, ALVAREZ M, AGUIRRE M, et. al. Efecto “in vitro” del formocresol y el sulfato férrico sobre macrófagos peritoneales murinos. Comunicaciones Científicas y Tecnológicas. Universidad Nacional del Nordeste, Argentina. M-095. 2006.
[14] ARSHADY R. Microsphere, microcapsule & liposome radioladeled and magnetic particulates in medicine y biology. Vol. 3. Londres: Citus Books; 2001. p. 99.
[15] ANGHILERI LJ. In Vivo Distribution of radioactive chromic phosphate: influence of the particle size and route of injection. Int J. Appl. Radiat. Isotop. 1965; 16(11): 623-630.
[16] ANGHILERI LJ, MARQUES R. New colloidal chromic radiophosphate for local iIrradiation of the central nervous systema. Int. J. Appl. Radiat. Isotop. 1967; 18(2): 97-100.
[17] ANGHILERI LJ, PRPIC B. A New colloidal (68Ga)-compound for liver scanning. Int. J. Appl. Radiat. Isotop. 1967; 18(2): 734-735.
[18] LEVINE B, HOFFMAN H, FREEDLANDER S. Distribution and effect of colloidal chromic phosphate (32P) inyected into the hepatic artery and portal vein of dogs and man. Cancer 1957; 10(1): 164-172.
[19] COOPER JAD, ZORN EM. Distribution of colloidal chromic phosphate after intracavitary administration in the rat. J Lab Clin Med. 1954; 42(6): 867-871.
[20] RESKE SN, VYSKA K, FEINENDEGEN LE. In Vivo Assessment of phagocytic properties of kupfer cells. J. Nucl. Med. 1981; 22(5): 405-410.