Nuclear cardiology in Cuba
Main Article Content
Abstract
This paper is a brief summary of the Nuclear Cardiology history in Cuba, mentioning the current main mortality causes, the usefulness and results of nuclear tests among the imaging techniques nowadays used in Cardiology, including gated-SPECT, PET and hybrid imaging combining anatomical and functional information. This paper also reviews our present worldwide performance in Nuclear Cardiology, with emphasis on our development and future trends, and proposes some recommendations.
Article Details
How to Cite
Peix González, A. (1). Nuclear cardiology in Cuba. Nucleus, (56). Retrieved from http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/596
Section
Panorama Nuclear
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References
[1] FRÁNQUIZ JM, CÁRDENAS R, LORD E, GARCÍA BARRETO D. Measurement of right and left ventricular ejection fractions by gated equilibrium scintigraphy using Fourier functional images. Nuklearmedizin. 1982; 21(4): 131-135.
[2] GONZÁLEZ GÓMEZ A, GARCÍA BARRETO D, FRÁNQUIZ JM. Hemodynamic effects of atenolol in labile hypertension. Arch Int Pharmacodyn Ther. 1983; 261(2): 260-267.
[3] BATISTA JF, PEREZTOL O, VALDÉS JA, et. al. Improved detection of myocardial perfusion reversibility by rest-nitroglycerin Tc-99m- MIBI: comparison with TI-201 reinjection. J Nucl Cardiol. 1999; 6(5): 480-486.
[4] PEREZTOL O, BATISTA JF, VALDÉS JA, et. al. Myocardial reversibility
detection. Rest NTG 99mTc-MIBI versus 201Tl reinjection. Preliminary results. J Radioanal Nucl Chem. 1999; 240(2): 489- 497.
[5] ROCHELA LM, PRATS A, COCA M, et. al. Comparación entre 99mTc-MIBI y 99mTc-tetrofosmina en la detección de la enfermedad coronaria [artículo en línea]. ALASBIMN Journal. 2003; 6(22). Article N° AJ22- 2. Disponible en : http://www.alasbimnjournal. cl/ [consulta: 16/09/2014 ]
[6] ROCHELA LM, PRATS A, BATISTA JF, et. al. Diferencias gammagráficas
de los infartos miocárdicos Q y no-Q estimada por SPECT [artículo en línea]. ALASBIMN Journal. 2004; 6(23). Article N° AJ23-5. Disponible en : http://www.alasbimnjournal.cl/ [consulta: 15/09/2014 ]
[7] ROCHELA LM, FERNÁNDEZ BRITTO JE, BACALLAO J, et. al. Correlación de los resultados del SPECT de Perfusión Miocárdica con 99mTc-MIBI con la presencia de Factores Mayores de Riesgo Aterosclerótico, en pacientes 40 años de edad (resultados preliminares). ALASBIMN Journal 2008; 10 (41). Article N° AJ41-3. Disponible en : http://www.alasbimnjournal.cl/ [consulta:
16/09/2014]
[8] ROCHELA LM, BATISTA JF, PEIX A, et. al. Asociación de los resultados positivos del SPECT de perfusión miocárdica con 99MTC-MIBI, con la presencia de Diabetes Mellitus en pacientes? 40 años de edad. Septiembre/2011. ISBN: 978-987-22746-1-0. Disponible en: http://www.fac.org.ar/7cvc/llave/tl008/tl008.php
[9] PEÑA Y, FERNÁNDEZ BRITTO JE, BACALLAO J, et. al. Lipid levels as predictors of silent myocardial ischemia in a type 2 diabetic population in Havana. MEDICC Rev. 2012; 14(1): 18-24.
[10] GONZÁLEZ GÓMEZ A, FRÁNQUIZ J, GARCÍA BARRETO D. Time course of cardiac performance in hypertensive patients after verapamil assessed by nuclear ventriculography. Int J Clin Pharmacol Ther Toxicol. 1990; 28(7): 292-297.
[11] GARCÍA BARRETO D, FRÁNQUIZ J, SÁNCHEZ CATASÚS C, et. al. The hemodynamics of oral nicardipine determined by radioisotope ventriculography in patients with ischemic cardiopathy. Arch Inst Cardiol Mex. 1991; 61(1): 21-25.
[12] FRÁNQUIZ JM, CABRERA C, DORTICÓS F, MALTAS AM. Valor de la ventriculografía isotópica en el pronóstico y seguimiento de los pacientes sometidos a miocardioplastia dinámica. Rev Esp Cardiol. 1992; 45(6): 381-385.
[13] FRÁNQUIZ JM, CABRERA C, DORTICÓS F, et. al. Assessment of left ventricular function by equilibrium-gated angiography before and following latissimus dorsi cardiomyoplasty in dilated cardiomyopathy. Am J Noninvas Cardiol. 1992; 6(3): 197-200.
[14] PEIX A, TAÍN J, CABRERA C, et. al. Radionuclide ventriculography
in dynamic cardiomyoplasty. J Nucl Biol Med. 1994; 38(4): 535-539.
[15] MENDIS S, PUSKA P, NORVVING B. Global atlas on cardiovascular
disease prevention and control. Geneva: World Health Organization,
2011.
[16] Anuario estadístico del MINSAP 2013. Disponible en http://www.
sld.cu. [consulta: 15/09/2014]
[17] KERWIN WF, BOTVINICK EH, O’CONNELL JW, et. al. Ventricular
contraction abnormalities in dilated cardiomyopathy: effect of biventricular
pacing to correct interventricular dyssynchrony. J Am Coll Cardiol. 2000; 35(5): 1221-1227.
[18] FAUCHIER L, MARIE O, CASSET SENON D, et. al. Interventricular and intraventricular dyssynchrony in idiopathic dilated cardiomyopathy: a prognostic study with fourier phase analysis of radionuclide angioscintigraphy. J Am Coll Cardiol. 2002; 40(11): 2022-2030.
[19] TOUSSAINT JF, PEIX A, LAVERGNE T, et. al. Reproducibility of the ventricular synchronization parameters assessed by multiharmonic phase analysis of radionuclide angiography in the normal heart. Int J Cardiovasc Imaging. 2002; 18(3): 187-194.
[20] PEIX A, PONCE F, ZAYAS R, et. al. Evaluación de la sincronización
ventricular por análisis de fase de Fourier en una ventriculografía
radioisotópica. Rev Esp Med Nuclear. 2003; 22(1): 26-29.
[21] CHEN J, GARCIA EV, FOLKS RD, et. al. Onset of left ventricular
mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: Development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol. 2005; 12(6): 687-695.
[22] ALJAROUDI W, KONERU J, HEO J, ISKANDRIAN AE. Impact of ischemia on left ventricular dyssynchrony by phase analysis of gated single photon emission computed tomography myocardial perfusion imaging. J Nucl Cardiol. 2011; 18(1): 36-42.
[23] CHEN CC, SHEN TY, CHANG MC, et. al. Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2012; 39(12): 1904-1909.
[24] PEIX A, KARELL J, RODRÍGUEZ L, et. al. Gated SPECT myocardial
perfusion imaging, intraventricular synchronism, and cardiac events in heart failure. Clin Nucl Med. 2014; 39(6): 498-504.
[25] ESTEVES FP, GALT JR, FOLKS RD, et. al. Diagnostic performance of low-dose rest/stress Tc-99m tetrofosmin myocardial perfusion SPECT using the 530c CZT camera: Quantitative vs visual analysis. J Nucl Cardiol. 2014; 21(1): 158–165.
[26] ABRAHAM A, NICHOL G, WILLIAMS KA, et. al. 18F-FDG PET imaging of myocardial viability in an experienced center with access to 18FDG and integration with clinical management teams: The Ottawa-FIVE substudy of the PARR 2 trial. J Nucl Med. 2010; 51(4): 567-574.
[27] ZIADI MC, BEANLANDS RS. The clinical utility of assessing myocardial
blood flow using positron emission tomography. J Nucl Cardiol. 2010; 17(4): 571-581.
[28] PEIX A, LLERENA L, PONCE F, et. al. Irradiación intracoronaria con renio 188 para reducir la restenosis después de la angioplastia coronaria. Resultados preliminares. Nucleus. 2003; (33): 41-44.
[29] HAGE FG, LUSA L, DONDI M, et. al. Exercise stress tests for detecting myocardial ischemia in asymptomatic patients with diabetes mellitus. Am J Cardiol. 2013; 112(1): 14-20.
[30] PEIX A, CABRERA LO, HERES F, et. al. Interrelationship between
myocardial perfusion imaging, coronary calcium score, and endothelial
function in asymptomatic diabetes and controls. J Nucl Cardiol. 2011; 18(3): 398-406.
[31] BETTER N, KARTHIKEYAN G, VITOLA J, et. al. Performance of rest myocardial perfusion imaging in the management of acute chest pain in the emergency room in developing nations (PREMIER trial). J Nucl Cardiol. 2012; 19(6): 1146-1153.
[32] PEIX A, BATISTA E, CABRERA LO, et. al. Gated-SPECT myocardial
perfusion imaging and coronary calcium score for evaluation of patients with acute chest pain and a normal or nondiagnostic electrocardiogram. Coron Artery Dis. 2012; 23(7): 438-444.
[33] MUT F, GIUBBINI R, VITOLA J, et. al. Detection of post-exercise
stunning by early gated SPECT myocardial perfusion imaging: Results from the IAEA multi-center study. J Nucl Cardiol. 2014; 21(6): 1168-1176.
[34] PEIX A, TRÁPAGA A, ASEN L, et. al. Mental stress-induced myocardial
ischemia in women with angina and normal coronary angiograms. J Nucl Cardiol. 2006; 13(4): 507-513.
[35] PEIX A, GARCÍA EJ, VALIENTE J, et. al. Ischemia in women with angina and normal coronary angiograms. Coron Artery Dis. 2007; 18(5): 361-366.
[36] PEIX A, GONZÁLEZ A, GARCÍA EJ, et. al. Left ventricular dysfunction
secondary to ischemia in women with angina and normal coronary angiograms. J Womens Health. 2009; 18(2): 155-161.
[37] PEIX A, LÓPEZ A, PONCE F, et. al. Enhanced detection of reversible
myocardial hypoperfusion by technetium 99m-tetrofosmin imaging and first-pass radionuclide angiography after nitroglycerin administration. J Nucl Cardiol. 1998; 5(5): 469-476.
[38] PEIX A, LLERENA L, LÓPEZ A, et. al. Radionuclide angiography after nisoldipine to detect myocardial viability. Rev. Federación Argentina Cardiología. 2000; 29(4): 527-529.
[39] CABRERA RODRÍGUEZ LO, PEIX A, PADRÓN KM, et. al. Prognostic value of gated SPECT after reperfusion for acute myocardial infarction. MEDICC Review. 2013; 15(2): 20-25.
[40] CABRERA L, GARCÍA R, QUIRÓS J, PEIX A. Tako-Tsubo Syndrome: Atypical nuclear medicine findings. World J of Nucl Medicine. 2012; 11(1): 35-38.
[41] PEIX A, MESQUITA CT, PAEZ D, et. al. Nuclear medicine in the
management of patients with heart failure: guidance from an expert panel of the International Atomic Energy Agency (IAEA). Nucl Med Commun. 2014; 35(8): 818-823.
[42] KAUFMANN PA, DICARLI M. Hybrid SPECT/CT and PET/CT imaging: The next step in noninvasive cardiac imaging. Semin Nucl Med. 2009; 39(5): 341-347.
[43] ISKANDRIAN AE. Myocardial perfusion imaging: Lessons learned and work to be done. J Nucl Cardiol. 2014; 21(1): 4-16.
[44] GAEMPERLI O, KAUFMANN PA. Hybrid cardiac imaging: more than the sum of its parts?. J Nucl Cardiol. 2008; 15(1): 123-126.
[2] GONZÁLEZ GÓMEZ A, GARCÍA BARRETO D, FRÁNQUIZ JM. Hemodynamic effects of atenolol in labile hypertension. Arch Int Pharmacodyn Ther. 1983; 261(2): 260-267.
[3] BATISTA JF, PEREZTOL O, VALDÉS JA, et. al. Improved detection of myocardial perfusion reversibility by rest-nitroglycerin Tc-99m- MIBI: comparison with TI-201 reinjection. J Nucl Cardiol. 1999; 6(5): 480-486.
[4] PEREZTOL O, BATISTA JF, VALDÉS JA, et. al. Myocardial reversibility
detection. Rest NTG 99mTc-MIBI versus 201Tl reinjection. Preliminary results. J Radioanal Nucl Chem. 1999; 240(2): 489- 497.
[5] ROCHELA LM, PRATS A, COCA M, et. al. Comparación entre 99mTc-MIBI y 99mTc-tetrofosmina en la detección de la enfermedad coronaria [artículo en línea]. ALASBIMN Journal. 2003; 6(22). Article N° AJ22- 2. Disponible en : http://www.alasbimnjournal. cl/ [consulta: 16/09/2014 ]
[6] ROCHELA LM, PRATS A, BATISTA JF, et. al. Diferencias gammagráficas
de los infartos miocárdicos Q y no-Q estimada por SPECT [artículo en línea]. ALASBIMN Journal. 2004; 6(23). Article N° AJ23-5. Disponible en : http://www.alasbimnjournal.cl/ [consulta: 15/09/2014 ]
[7] ROCHELA LM, FERNÁNDEZ BRITTO JE, BACALLAO J, et. al. Correlación de los resultados del SPECT de Perfusión Miocárdica con 99mTc-MIBI con la presencia de Factores Mayores de Riesgo Aterosclerótico, en pacientes 40 años de edad (resultados preliminares). ALASBIMN Journal 2008; 10 (41). Article N° AJ41-3. Disponible en : http://www.alasbimnjournal.cl/ [consulta:
16/09/2014]
[8] ROCHELA LM, BATISTA JF, PEIX A, et. al. Asociación de los resultados positivos del SPECT de perfusión miocárdica con 99MTC-MIBI, con la presencia de Diabetes Mellitus en pacientes? 40 años de edad. Septiembre/2011. ISBN: 978-987-22746-1-0. Disponible en: http://www.fac.org.ar/7cvc/llave/tl008/tl008.php
[9] PEÑA Y, FERNÁNDEZ BRITTO JE, BACALLAO J, et. al. Lipid levels as predictors of silent myocardial ischemia in a type 2 diabetic population in Havana. MEDICC Rev. 2012; 14(1): 18-24.
[10] GONZÁLEZ GÓMEZ A, FRÁNQUIZ J, GARCÍA BARRETO D. Time course of cardiac performance in hypertensive patients after verapamil assessed by nuclear ventriculography. Int J Clin Pharmacol Ther Toxicol. 1990; 28(7): 292-297.
[11] GARCÍA BARRETO D, FRÁNQUIZ J, SÁNCHEZ CATASÚS C, et. al. The hemodynamics of oral nicardipine determined by radioisotope ventriculography in patients with ischemic cardiopathy. Arch Inst Cardiol Mex. 1991; 61(1): 21-25.
[12] FRÁNQUIZ JM, CABRERA C, DORTICÓS F, MALTAS AM. Valor de la ventriculografía isotópica en el pronóstico y seguimiento de los pacientes sometidos a miocardioplastia dinámica. Rev Esp Cardiol. 1992; 45(6): 381-385.
[13] FRÁNQUIZ JM, CABRERA C, DORTICÓS F, et. al. Assessment of left ventricular function by equilibrium-gated angiography before and following latissimus dorsi cardiomyoplasty in dilated cardiomyopathy. Am J Noninvas Cardiol. 1992; 6(3): 197-200.
[14] PEIX A, TAÍN J, CABRERA C, et. al. Radionuclide ventriculography
in dynamic cardiomyoplasty. J Nucl Biol Med. 1994; 38(4): 535-539.
[15] MENDIS S, PUSKA P, NORVVING B. Global atlas on cardiovascular
disease prevention and control. Geneva: World Health Organization,
2011.
[16] Anuario estadístico del MINSAP 2013. Disponible en http://www.
sld.cu. [consulta: 15/09/2014]
[17] KERWIN WF, BOTVINICK EH, O’CONNELL JW, et. al. Ventricular
contraction abnormalities in dilated cardiomyopathy: effect of biventricular
pacing to correct interventricular dyssynchrony. J Am Coll Cardiol. 2000; 35(5): 1221-1227.
[18] FAUCHIER L, MARIE O, CASSET SENON D, et. al. Interventricular and intraventricular dyssynchrony in idiopathic dilated cardiomyopathy: a prognostic study with fourier phase analysis of radionuclide angioscintigraphy. J Am Coll Cardiol. 2002; 40(11): 2022-2030.
[19] TOUSSAINT JF, PEIX A, LAVERGNE T, et. al. Reproducibility of the ventricular synchronization parameters assessed by multiharmonic phase analysis of radionuclide angiography in the normal heart. Int J Cardiovasc Imaging. 2002; 18(3): 187-194.
[20] PEIX A, PONCE F, ZAYAS R, et. al. Evaluación de la sincronización
ventricular por análisis de fase de Fourier en una ventriculografía
radioisotópica. Rev Esp Med Nuclear. 2003; 22(1): 26-29.
[21] CHEN J, GARCIA EV, FOLKS RD, et. al. Onset of left ventricular
mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: Development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol. 2005; 12(6): 687-695.
[22] ALJAROUDI W, KONERU J, HEO J, ISKANDRIAN AE. Impact of ischemia on left ventricular dyssynchrony by phase analysis of gated single photon emission computed tomography myocardial perfusion imaging. J Nucl Cardiol. 2011; 18(1): 36-42.
[23] CHEN CC, SHEN TY, CHANG MC, et. al. Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2012; 39(12): 1904-1909.
[24] PEIX A, KARELL J, RODRÍGUEZ L, et. al. Gated SPECT myocardial
perfusion imaging, intraventricular synchronism, and cardiac events in heart failure. Clin Nucl Med. 2014; 39(6): 498-504.
[25] ESTEVES FP, GALT JR, FOLKS RD, et. al. Diagnostic performance of low-dose rest/stress Tc-99m tetrofosmin myocardial perfusion SPECT using the 530c CZT camera: Quantitative vs visual analysis. J Nucl Cardiol. 2014; 21(1): 158–165.
[26] ABRAHAM A, NICHOL G, WILLIAMS KA, et. al. 18F-FDG PET imaging of myocardial viability in an experienced center with access to 18FDG and integration with clinical management teams: The Ottawa-FIVE substudy of the PARR 2 trial. J Nucl Med. 2010; 51(4): 567-574.
[27] ZIADI MC, BEANLANDS RS. The clinical utility of assessing myocardial
blood flow using positron emission tomography. J Nucl Cardiol. 2010; 17(4): 571-581.
[28] PEIX A, LLERENA L, PONCE F, et. al. Irradiación intracoronaria con renio 188 para reducir la restenosis después de la angioplastia coronaria. Resultados preliminares. Nucleus. 2003; (33): 41-44.
[29] HAGE FG, LUSA L, DONDI M, et. al. Exercise stress tests for detecting myocardial ischemia in asymptomatic patients with diabetes mellitus. Am J Cardiol. 2013; 112(1): 14-20.
[30] PEIX A, CABRERA LO, HERES F, et. al. Interrelationship between
myocardial perfusion imaging, coronary calcium score, and endothelial
function in asymptomatic diabetes and controls. J Nucl Cardiol. 2011; 18(3): 398-406.
[31] BETTER N, KARTHIKEYAN G, VITOLA J, et. al. Performance of rest myocardial perfusion imaging in the management of acute chest pain in the emergency room in developing nations (PREMIER trial). J Nucl Cardiol. 2012; 19(6): 1146-1153.
[32] PEIX A, BATISTA E, CABRERA LO, et. al. Gated-SPECT myocardial
perfusion imaging and coronary calcium score for evaluation of patients with acute chest pain and a normal or nondiagnostic electrocardiogram. Coron Artery Dis. 2012; 23(7): 438-444.
[33] MUT F, GIUBBINI R, VITOLA J, et. al. Detection of post-exercise
stunning by early gated SPECT myocardial perfusion imaging: Results from the IAEA multi-center study. J Nucl Cardiol. 2014; 21(6): 1168-1176.
[34] PEIX A, TRÁPAGA A, ASEN L, et. al. Mental stress-induced myocardial
ischemia in women with angina and normal coronary angiograms. J Nucl Cardiol. 2006; 13(4): 507-513.
[35] PEIX A, GARCÍA EJ, VALIENTE J, et. al. Ischemia in women with angina and normal coronary angiograms. Coron Artery Dis. 2007; 18(5): 361-366.
[36] PEIX A, GONZÁLEZ A, GARCÍA EJ, et. al. Left ventricular dysfunction
secondary to ischemia in women with angina and normal coronary angiograms. J Womens Health. 2009; 18(2): 155-161.
[37] PEIX A, LÓPEZ A, PONCE F, et. al. Enhanced detection of reversible
myocardial hypoperfusion by technetium 99m-tetrofosmin imaging and first-pass radionuclide angiography after nitroglycerin administration. J Nucl Cardiol. 1998; 5(5): 469-476.
[38] PEIX A, LLERENA L, LÓPEZ A, et. al. Radionuclide angiography after nisoldipine to detect myocardial viability. Rev. Federación Argentina Cardiología. 2000; 29(4): 527-529.
[39] CABRERA RODRÍGUEZ LO, PEIX A, PADRÓN KM, et. al. Prognostic value of gated SPECT after reperfusion for acute myocardial infarction. MEDICC Review. 2013; 15(2): 20-25.
[40] CABRERA L, GARCÍA R, QUIRÓS J, PEIX A. Tako-Tsubo Syndrome: Atypical nuclear medicine findings. World J of Nucl Medicine. 2012; 11(1): 35-38.
[41] PEIX A, MESQUITA CT, PAEZ D, et. al. Nuclear medicine in the
management of patients with heart failure: guidance from an expert panel of the International Atomic Energy Agency (IAEA). Nucl Med Commun. 2014; 35(8): 818-823.
[42] KAUFMANN PA, DICARLI M. Hybrid SPECT/CT and PET/CT imaging: The next step in noninvasive cardiac imaging. Semin Nucl Med. 2009; 39(5): 341-347.
[43] ISKANDRIAN AE. Myocardial perfusion imaging: Lessons learned and work to be done. J Nucl Cardiol. 2014; 21(1): 4-16.
[44] GAEMPERLI O, KAUFMANN PA. Hybrid cardiac imaging: more than the sum of its parts?. J Nucl Cardiol. 2008; 15(1): 123-126.