Technological and engineering solutions in the radiopharmaceuticals production

Main Article Content

Ángel L. González Fernández
Lázaro Falcón Pérez

Abstract

The paper discusses the conception and original design of the Isotope Centre’s facilities, and structural changes made to the centre over 15 years of operation with the aim of meeting the Good Manufacturing Practices Regulations nonexistent at the time of its commissioning. Particular emphasis is given to the changes made to hot cells, glove boxes, and also some aspects related to technological processes. As a result, the CENTIS productions fulfil international standards and its facilities have been validated in correspondence with the national regulations. Steps are directed not only to meet the requirements of ISO 9000 and GMP, but to ensure optimization and flexibility in the use of the facilities.

Article Details

How to Cite
González Fernández, Ángel L., & Falcón Pérez, L. (1). Technological and engineering solutions in the radiopharmaceuticals production. Nucleus, (52). Retrieved from http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/566
Section
Innovación Tecnológica

References

1.- IAEA. Radioisotope handling facilities and automation of radioisotope production. IAEA-TECDOC-1430. Vienna: IAEA, 2004.
2.- CRUZ ARENCIBIA J. Instalaciones de Producción de Radiofármacos y Aseguramiento de la Calidad en el Centro de Isótopos. Desarrollo y Perspectivas. Nucleus. 2003; (33): 10-16.