Design and optimization of a beam-shaping assembly for BNCT based on a neutron generator
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Abstract
A monoenergetic neutron beam simulation study is carried out to determine the most suitable neutron energy for treatment of shallow and deep-seated brain tumors in the context of Boron Neutron Capture Therapy. Two figures-of-merit, i.e. the absorbed dose for healthy tissue and the absorbed tumor dose at a given depth in the brain are used to measure the neutron beam quality. Also irradiation time, therapeutic gain and the power generated in the target are utilized as beam assessment parameters. Moderators, reflectors and delimiters are designed and optimized to moderate the high-energy neutrons from the fusion reactions .(d;n) and (d;n) down to a suitable energy spectrum. Metallic uranium and manganese are successfully tested for fast-to-epithermal neutron moderation as well as Fluental for the neutron spectrum shifting. A semispherical target is proposed in order to dissipate twice the amount of power generated in the target, and decrease all the dimensions of the BSA. The cooling system of the target is also included in the calculations. Calculations are performed using the MCNP code. After the optimization of our beam-shaper a study of the dose distribution in the head had been made. The therapeutic gain is increased in 9% while the current required for one hour treatment is decreased in comparison with the trading prototypes of NG used for Boron Neutron Capture Therapy.
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Padilla Cabal, F., Martín Hernández, G., & Abrahantes Quintana, A. (1). Design and optimization of a beam-shaping assembly for BNCT based on a neutron generator. Nucleus, (41). Retrieved from http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/491
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Ciencias Nucleares
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References
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2. VERBEKE JM, LEE Y, VUJIC J, LEUNG KN. Compact accelerator and beam shaping assembly design for BNCT based on the D-T fusion reaction.
3. NIAS AHW. An Introduction to Radiobiology. New York: John Wiley & Sons, 1990.
4. MARTIN G, ABRANTES A. A conceptual design of a beam shaping assembly for BNCT based on DT neutron generators. Med Phys. 2004;( 31).
5. MARTIN G. A method for fast evaluation of neutron spectra for BNCT based on in-phantom figure-of-merit calculation. Med. Phys. 2003; 30 (3).
6. SNYDER WS, FORD MR, WAGNER GG, FISHER HL. Estimates of absorbed fractions for monoenergetic photon sources uniformly distributed in various organs of heterogeneous phantom MIRD. J. Nucl. Med. 1978; (Suppl. 3, Pamphlet 5).
7. LIU HB, GREENBERG DD, CAPALA J, WHEELER FJ. An improved neutron collimator for brain tumor irradiations in clinical boron neutron capture therapy. Med. Phys. 1996; (23).
8. BROOKS RA, DICHIRO G, KELLER MR. Explanation of cerebral white-gray contrast in computed tomography. J. Comput. Assist. Tomogr. 1980; (4).
9. SUNG-JOON YE. Boron self-shielding effects on dose delivery of neutron capture therapy using epithermal beam and boronophenylalanine. Med. Phys. 1999; (26).
10. BLUE TE, WOLLARD JE, GUPTA N, GRESKOVICH JF. An expression for the RBE of neutrons as a function of neutron energy . Phys. Med. Biol. 1995; (40).