Nuevo radioinmunoconjugado -dota-h-r3. Sintesis y radiomarcaje

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Denis R. Beckford Vera
Abmel Xiques Castillo
Rene Leyva Montana
Marylaine Perez Malo Cruz
Edgar Casanova Gonzalez
Minely Zamora Barrabi

Resumen

El marcaje de anticuerpos monoclonales con metales radiactivos para diagnóstico y terapia generalmente involucra el uso de agentes quelatantes bifuncionales que contienen una función reactiva para conjugarse con las proteínas y un grupo capaz de enlazar fuertemente al metal formando complejos fisiológicamente estables. El objetivo del trabajo fue modificar el anticuerpo monoclonal humanizado (h-R3) con el ácido 1,4,7,10-tetraazaciclododecano-N,N´,N´´,N´´´-tetraacético (DOTA) en solución acuosa, realizar el marcaje de los conjugados obtenidos con y estudiar algunas de las variables que influyen en la reacción, así como la estabilidad del radioinmunoconjugado en presencia de otros agentes quelatantes.

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Cómo citar
Beckford Vera, D. R., Xiques Castillo, A., Leyva Montana, R., Perez Malo Cruz, M., Casanova Gonzalez, E., & Zamora Barrabi, M. (1). Nuevo radioinmunoconjugado -dota-h-r3. Sintesis y radiomarcaje. Nucleus, (41). Recuperado a partir de http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/486
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Ciencias Nucleares

Citas

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