The mile-stone of PET radiopharmaceuticals development
Main Article Content
Abstract
The positron emitting nuclides were already tried in 1940's as in vivo radio-tracers in the research field of medical biology. In 1976, the discovery of 18FDG with the developing of a positron imaging device, allowed to obtain the image of the human brain by PET technology. Today, 18FDG is widely used in tumour diagnosis by a metabolic trapping mechanism, which is a new concept for functional imaging and makes possible the monitoring of the therapy process. This is first milestone of PET radiopharmaceutical development. The second milestone is the establishment of a molecular imaging method in nuclear medicine and third, is the development of the theragnostic concept of radiopharmaceuticals. At present highlight works are focused in tau protein imaging for Alzheimer disease diagnosis and inflammation imaging.
Article Details
How to Cite
Ido, T., & Valdés, T. (1). The mile-stone of PET radiopharmaceuticals development. Nucleus, (60). Retrieved from http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/629
Section
Ciencias Nucleares
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista. Bajo esta licencia el autor será libre de:
- Compartir — copiar y redistribuir el material en cualquier medio o formato
- Adaptar — remezclar, transformar y crear a partir del material
- El licenciador no puede revocar estas libertades mientras cumpla con los términos de la licencia
Bajo las siguientes condiciones:
- Reconocimiento — Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace.
- NoComercial — No puede utilizar el material para una finalidad comercial.
- No hay restricciones adicionales — No puede aplicar términos legales o medidas tecnológicas que legalmente restrinjan realizar aquello que la licencia permite.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).
La Revista Nucleus solo aceptará contribuciones que no hayan sido previamente publicados y/o procesados, por otra publicación. Cualquier violación ese sentido será considerada una falta grave por parte del autor principal lo cual será objeto valoración por parte del Consejo Editorial, el cual dictaminará al respecto.
References
[1] IDO T, WON CN, FOWLER JS, WOLF AP. Fluorination with F2. A Convenient Synthesis of 2-Deoxy-2-fluoo-D-glucose. J. Org. Chem. 1977; 42 (13): 2341-2342.
[2] IDO T, WON CN, CASELLA V, et. al. Labeled 2-deoxy-D-glucose analog. 18F-labeled 2-deoxy-2-fuluoro-D-glucose, 2-deoxy-2-fluoo-D-mannose and 14C-2-deoxy-2-fuluoro-D-glucose. J of Labelled Comp. and Radiopharm. 1978; 16(2): 175-183.
[3] REIVICH M, KUHL D, WOLF A, GREENBERG J, PHELPS M, IDO T, et. al. The [18F]Fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circulation Research. 1979; 44(1): 127-137.
[4] ISHIWATA K, IDO T, KAWAMURA M, et. al. 4-Boron-2-[18F]Fluoro-D,L-phenylalanine as a target compound for boron neutron capture therapy: tumour imaging potential with positron emission tomography. Nucl. Med. Biol. 1991; 18(7): 745-751.
[5] IMAHORI Y, UEDA S, OHMORI Y, KUSAKI T, ONO K, FUJII R, IDO T. Fruorine-18-labeled fluooboronophenylalanine PET in patients with glioma. J. Nucl. Med. 1998; 39(2): 325-333.
[6] TAKAHASHI T, IDO T, IWATA R. Synthesis of 17-[18F]fluoo-5-methylpentadecanoic Acid. Appl. Radiat. Isot. 1992; 43(6): 822-824.
[7] TAKAHASHI T, NISHIMURA S, IDO T, ISHIWATA K, IWATA R. Biological evaluation of 5-Methyl-branched-chain ?-[18F]Fluorofatty acid: a potencial myocardial imaging tracer for positron emission tomography. Nucl. Med. Biol. 1996; 23(3): 303-308.
[8] HATANO K, ISHIWATA K, KAWASHIMA K, HATAZAWA J, ITOH M, IDO T. D2-Dopamine receptor specificbrain uptake of carbon-11-labeled YM-09151-2. J. NUC. Med. 1989; 30(4): 515-522.
[9] ISHIWATA K, YANAI K, IDO T, MIURA Y, KAWASHMA K. Synthesis and biodistribution of [11C] fludiazepam for imaging benzodiazepine receptors. Nucl. Med. Biol. 1988; 15(4): 365-371.
[10] YANAI K, WATANABE T, YOKOYAMA H, MEGRO K, HATAZAWA J, ITOH M, et.al. Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and emission tomography. Neuroscience Letters. 1992; 137(2): 145-148.
[11] YANAI K, RYU JH, WATANABE T, IWATA R, IDO T, SAWAI Y, et. al. Histamine H1 receptor occupancy in human brain after single doses of histamine H1 antagonist measured by positron emission tomography. British J Pharmacology. 1995; 116(1): 1649-1655.
[12] HOLLAND JP, SHEH Y, LEWIS JS. Standardized methods for the production of high specific-activity zirconium-89. Nucl. Med. Biol. 2009; 36(7): 729-739.
[13] HOLLAND JP, DIVILOV V, BANDER NH, SMIS-JONES PM, LAR-SO N SM, LEVIS JS. 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo. J. Nucl. Med. 2010; 51(8): 1293-1300.
[14] van de WATERRING FCJ, RIJPKEMA M, PERK L, BRINKMANN U, OYEN WJG, BOERMAN OC. Zirconium-89 labeled antibodies: a new tool for molecular imaging in cancer patients (review). BioMed Res Int. 2014; Article ID 203601 http://www.hindawi.com/journals/bmri/2014/203601.
[15] XIA CF, ARTEAGA J, CHEN G, GANGADHARMATH U, GOMEZ LF, et. al. [18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimer’s and Dementia. 2013; 9(6): 666-676.
[16] VILLEMAGNE VL, OKAMURA N. In vivo tau imaging: obstacle and progress. Alzheimer's and Dementia. 2014; 10(3): 254-264.
[17] HARADA R, OKAMURA N, FURUMOTO S, FURUKAWA K, ISHIKI A, TOMITA N, et. al. [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging. 2015; 42(7): 1052-1061.
[2] IDO T, WON CN, CASELLA V, et. al. Labeled 2-deoxy-D-glucose analog. 18F-labeled 2-deoxy-2-fuluoro-D-glucose, 2-deoxy-2-fluoo-D-mannose and 14C-2-deoxy-2-fuluoro-D-glucose. J of Labelled Comp. and Radiopharm. 1978; 16(2): 175-183.
[3] REIVICH M, KUHL D, WOLF A, GREENBERG J, PHELPS M, IDO T, et. al. The [18F]Fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circulation Research. 1979; 44(1): 127-137.
[4] ISHIWATA K, IDO T, KAWAMURA M, et. al. 4-Boron-2-[18F]Fluoro-D,L-phenylalanine as a target compound for boron neutron capture therapy: tumour imaging potential with positron emission tomography. Nucl. Med. Biol. 1991; 18(7): 745-751.
[5] IMAHORI Y, UEDA S, OHMORI Y, KUSAKI T, ONO K, FUJII R, IDO T. Fruorine-18-labeled fluooboronophenylalanine PET in patients with glioma. J. Nucl. Med. 1998; 39(2): 325-333.
[6] TAKAHASHI T, IDO T, IWATA R. Synthesis of 17-[18F]fluoo-5-methylpentadecanoic Acid. Appl. Radiat. Isot. 1992; 43(6): 822-824.
[7] TAKAHASHI T, NISHIMURA S, IDO T, ISHIWATA K, IWATA R. Biological evaluation of 5-Methyl-branched-chain ?-[18F]Fluorofatty acid: a potencial myocardial imaging tracer for positron emission tomography. Nucl. Med. Biol. 1996; 23(3): 303-308.
[8] HATANO K, ISHIWATA K, KAWASHIMA K, HATAZAWA J, ITOH M, IDO T. D2-Dopamine receptor specificbrain uptake of carbon-11-labeled YM-09151-2. J. NUC. Med. 1989; 30(4): 515-522.
[9] ISHIWATA K, YANAI K, IDO T, MIURA Y, KAWASHMA K. Synthesis and biodistribution of [11C] fludiazepam for imaging benzodiazepine receptors. Nucl. Med. Biol. 1988; 15(4): 365-371.
[10] YANAI K, WATANABE T, YOKOYAMA H, MEGRO K, HATAZAWA J, ITOH M, et.al. Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and emission tomography. Neuroscience Letters. 1992; 137(2): 145-148.
[11] YANAI K, RYU JH, WATANABE T, IWATA R, IDO T, SAWAI Y, et. al. Histamine H1 receptor occupancy in human brain after single doses of histamine H1 antagonist measured by positron emission tomography. British J Pharmacology. 1995; 116(1): 1649-1655.
[12] HOLLAND JP, SHEH Y, LEWIS JS. Standardized methods for the production of high specific-activity zirconium-89. Nucl. Med. Biol. 2009; 36(7): 729-739.
[13] HOLLAND JP, DIVILOV V, BANDER NH, SMIS-JONES PM, LAR-SO N SM, LEVIS JS. 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo. J. Nucl. Med. 2010; 51(8): 1293-1300.
[14] van de WATERRING FCJ, RIJPKEMA M, PERK L, BRINKMANN U, OYEN WJG, BOERMAN OC. Zirconium-89 labeled antibodies: a new tool for molecular imaging in cancer patients (review). BioMed Res Int. 2014; Article ID 203601 http://www.hindawi.com/journals/bmri/2014/203601.
[15] XIA CF, ARTEAGA J, CHEN G, GANGADHARMATH U, GOMEZ LF, et. al. [18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimer’s and Dementia. 2013; 9(6): 666-676.
[16] VILLEMAGNE VL, OKAMURA N. In vivo tau imaging: obstacle and progress. Alzheimer's and Dementia. 2014; 10(3): 254-264.
[17] HARADA R, OKAMURA N, FURUMOTO S, FURUKAWA K, ISHIKI A, TOMITA N, et. al. [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging. 2015; 42(7): 1052-1061.