Gammagrafía de receptores de somatostatina con <sup>68</sup>Ga-DOTATATE PET/CT: experiencia inicial en Cuba

Contenido principal del artículo

Juan P. Oliva González

Resumen

En 1870 Rudolf Heidenhain descubrió las células neuroendocrinas, las cuales dan origen a los Tumores Neuroendocrinos (TNE) que son una forma rara de cáncer, la mayoría de los cuales expresan receptores de somatostatina. El fundamento de la Gammagrafía de Receptores como imagen metabólico-molecular se fundamenta en el empleo de 68Ga-DOTA-péptidos con enlazamiento específico a los receptores de somatostatina. La presente publicación tiene el propósito de dar a conocer nuestras primeras experiencias en el estudio de diferentes tipos histológicos de TNE por medio de la Gammagrafía de Receptores de Somatostatina (GRS) empleando el 68Ga-DOTATATE PET/CT realizados en el Centro PET/CT e incluyendo Imagen Molecular del Departamento de Medicina Nuclear del Instituto Nacional de Oncología y Radiobiología (Inor).

Detalles del artículo

Cómo citar
Oliva González, J. P. (1). Gammagrafía de receptores de somatostatina con <sup>68</sup&gt;Ga-DOTATATE PET/CT: experiencia inicial en Cuba. Nucleus, (62), 14-23. Recuperado a partir de http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/20
Sección
Panorama Nuclear

Citas

[1]. HEIDENHAIN R. Untersuchungen über den Bau der Labdrüsen. Arch für Mikrosk Anat. 1870; 6: 368-406.
[2]. BAUM RP, PURANIK, A KULKARNI HR. Peptide receptor radionuclide therapy(PRRT) of neuroendocrine tumors: current state and future perspectives. Int. J. End. Oncol. 2015; 2(2): 151-158.
[3]. MODLIN IM, OBERG K, CHUNG DC. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 2008; 9(1): 61-72.
[4]. MODLIN IM, LYE KD, KIDD M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003; 97(4): 934-959.
[5]. OBERNDORFER S. Karzinoide Handbuch der Speziellen. In: Handbuch der Speziellen Pathologischen Anatomie und Histalagie. Berlin, Germany: Verlag von Julius Springer; 1928. P. 814-817.
[6]. DEPPEN AD, LIU E, BLUME JD, et. al. Safety and efficacy of 68Ga-DOTATATE for diagnosis, staging and treatment management of neuroendocrine tumors. J Nucl Med. 2016; 57(5):708-714.
[7]. BAUM RP, HOFMANN M. Nuklearmedizinische diagnostik neuroendokriner tumoren. Onkologe 2004; 10(6): 598-610.
[8]. EHRLICH P. Croonian lecture: on immunity with special reference to cell life . Proc Royal Soc London. 1900; 66: 424-448.
[9]. BAUM RP, KULKARNI,HR, CARRERAS C. Peptides and receptors in Image-guided therapy: theranostics for neuroendocrine neoplasms. Semin Nucl Med. 2012; 42(3): 190-207.
[10]. BAUM RP, PRASAD V, HOMMAN, HÖRSCH D. Receptor PET(CT Imaging of Neuroendorine Tumors. Recent Results Cancer Res. 2008; 170: 225-42.
[11]. de HERDER WW, HOFLAND LJ, van der LELY AJ, LAMBERTS SW. Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours. EndocrRelat Cancer. 2003;10(4): 451-458.
[12]. MUELLER D, KLETTE I, BAUM RP, et. al. Simplified NaCl based 68Ga concentration and labeling procedure for rapid synthesis of 68Ga radiopharmaceuticals in high radiochemical purity. Bioconjug Chem. 2012; 23(8): 1712-1717.
[13]. SCHULTZ M, MUELLER D, BAUM RP, et. al. A new automated NaCl based robust method for routine production of gallium-68 labeled peptides. Appl Radiat Isot. 2013; 76: 46-54.
[14]. RUFINI V, CALCAGNI L., BAUM RP. Imaging of neuroendocrine tumors. Semin Nucl Med. 2006; 36(3): 228-247.
[15]. KULKARNI HR, SINGH A, BAUM RP. Advances in the diagnosis of neuroendocrine neoplasms. Semin Nucl Med. 2016; 46(5): 395-404.
[16]. HÖRSCH D, SCHMIDT KW, ANLAUF M, et. al. Neuroendocrine tumors of the bronchopulmonary system (typical and atypical carcinoid tumors): current strategies in diagnosis and treatment. Conclusions of an Expert Meeting February 2011 in Weimar, Germany. Oncol Res Treat. 2014; 37(5): 266-276.
[17]. BODEI L, KWEKKEBOOM DJ, KIDD M, et. al. Radiolabeled somatostatin analogue therapy of gastroenteropancreatic cancer. Semin Nucl Med. 2016; 46(3): 225-238.
[18]. GRAVEL G, .,GIMENEZ-ROQUEPLO, AP, HALIMI P. 68Ga-DOTATATE PET/CT Versus MRI: Why the Comparison of 68Ga-DOTATATE PET/CT to an Appropriate MRI Protocol Is Essential. J Nucl Med. 2017; 58(1): 184-185.
[19]. DEMIRC. E, AKYEL R., KILIC F, et. al. Dual false positive of 68 Ga-DOTA-TATE PET/CT scan in a patient with a history of pancreatic neuroendocrine tumor: A case report. Rev Esp Med Nucl Imagen Mol. 2015; 34(2): 133-135.
[20]. AGRAWAL K, ESMAIL AA, GNANASEGARAN G, et. al. Pitfalls and Limitations of Radionuclide Imaging in Endocrinology. Semin Nucl Med. 2015; 45(5): 440-457.
[21]. REUBI JC, WASER B. Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. . Eur J Nucl Med Mol Imaging. 2003; 30(5): 781-793.
[22]. REUBI JC. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev. 2003; 24(4): 389-427.
[23]. MAURICE JB, TROKE R, WIN Z, et. al. A comparison of the performande of 68Ga-DOTATATE PET/CT and 123I-MIBG SPECT in the diagnosis and follow-up of pheochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging. 2012; 39(8): 1266-1270.
[24]. AMBROSSINI V, CAMPANA D, BODEI L, et. al. 68Ga-DOFTANOC PET/CT clinical impact in patients with neuroendocrine tumors. J Nucl Med. 2010; 51(5): 669-773.
[25]. KULAKSIZ H, EISSELE R, ROESSLER D, et. al. Identification of somatostatin receptor subtypes 1, 2A, 3 and 5 in neuroendocrine tumours with subtype specific antibodies. Gut. 2002; 50(1): 52-60.
[26]. KWEKKEBOOM DJ, KAM BL, van ESSEN M, et. al. Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors. Endocr Relat Cancer. 2010; 17(1): R53-73.
[27]. KAEMMERER D, PETER L, LUPP A, et. al. Molecular imaging with 68Ga-SSTR PET/CT and correlation of immunohistochemistry of somatostatin receptors in neuroendocrine tumour. Eur J Nucl Med Mol Imaging. 2011; 38(9): 1659-1668.
[28]. KABASAKAL L, DEMIRCI E, OCAK, M, et. al. Comparison of 68Ga-DOTATATE and 68GA-DOTANOC PET/CT imaging in the same patient group with neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2012; 39(8): 1271-1277.
[29]. LAIRMORE TC, WELLS SA Jr. Medullary carcinoma of the thyroid: current diagnosis and management. Semin Surg Oncol.1991; 7(2): 92-99.
[30]. ORLANDINI F, CARACI P, MUSSA A. Treatment of medullary thyroid carcinoma: an update. Endocr Relat Cancer. 2001; 8(2): 135-147.
[31]. ABDELMOUMENE N, SCHLUMBERGER M, GARDET P. Selective venous sampling catheterization for localization of persisting medullary thyroid carcinoma. Br J Cancer.1994; 69(6): 1141-1144.
[32]. KEBEBEW E, ITUARTE PH, SIPERSTEIN AE. Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging system. Cancer. 2000; 88(5): 1139-1148.
[33]. SZAVCSUR P, GODENY M, BAJZIK G. Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients. Eur J Surg Oncol. 2005; 31(2): 183-190.
[34]. GAZTAMBIDE SD. Diagnóstico y clínica de los carcinoides intestinales. El síndrome carcinoide. Endocrinol Nutr. 2007; 54(Supl 1): 9-14
[35]. ÖBERG KE, REUBI JC, KWEKKEBOOM DJ, KRENNING EP. Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy. Gastroenterology. 2010; 139(3): 742-753.
[36]. SALAZAR R, VILLABONA C, FABREGAT J. Tumores neuroendocrinos gastrointestinales y pancreáticos. Med Clin. 2006; 127(6): 227-231.
[37]. VILLABONA C, CASANOVAS O, SALAZAR R. Biologia molecular, epidemiologia y clasificación de los tumores neurendocrinos gastroenetropancreáticos. Endocrinol Nutr. 2007; 54(Supl 1): 2-8.
[38]. SCIHILLING FH, BIHL H, JACOBSON H. Combined 111In Pentetrotide scintigraphy and 123ImIBG scintigraphy in neuroblastoma provides prognostic information. Med Pediatr Oncol. 2000; 35(6): 688-691.
[39]. KUSHNER BH. Neuroblastoma: a disease requiring a multitude of imaging studies. J Nucl Med. 2004; 45(7): 1172-1188.
[40]. SÁNCHEZ-GRANJEL M, BENITO F, BATUECAS A. Recuerdo histórico y epidemiología. Acta Otorrinolaringol Esp. 2009; 60 Supl. 1:3-8.
[41]. PÉREZ D, GUTIÉRREZ R, RAMOS A. Clasificación de los paragangliomas cervicocefálicos. Acta Otorrinolaringol Esp. 2009; 60(Supl. 1): 29-33.
[42]. TORRES MORIENTES LM, MENA DOMÍNGUEZ EA, FERNÁNDEZ RODRÍGUEZ A, et. al. Manejo de tres paragangliomas carotídeos y revisión del tema. Rev. Soc. Otorrinolaringol. Castilla Leon Cantab. La Rioja. 2014; 5(9): 75-84.
[43]. MUNDSCHENK J, UNGER N, SCHULZ S, et. al. Somatostatin receptor subtypes in human pheochromocytoma: subcellular expression pattern and functional relevance for octreotide scintigraphy. J Clin Endocrinol Metab. 2003; 88(11): 5150-5157.
[44]. HALPERIN I. Insulinoma. Endocrinol Nutr. 2007; 54(Supl1): 15-20.
[45]. OLIVA JP & BAUM RP. Dual tracer/dual isotope 68Ga-DOTANOC and 18F-FDG PET/CT: A one day protocol in a child with neuroblastoma for determining the receptor status and the metabolic tumor state. First World Congress of 68Ga-Somatostatine. Bad Berka. Turingia. Alemania. 2014.